Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 2/20 | 0.56 |
| ▸ | WDR5 | P61964 | 1/20 | 0.48 |
| ▸ | NQO2 | P16083 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8973453 | 0.91 | PRMT1 (0.51) | PRMT1WDR5NQO2ALDH1A1TOP1 | |
| SCHEMBL8975508 | 0.87 | PRMT1 (0.71) | PRMT1WDR5NQO2ALDH1A1TOP1 | |
| SCHEMBL14369775 | 0.83 | PRMT1 (0.50) | PRMT1WDR5NQO2ALDH1A1HPGD | |
| SCHEMBL14155399 | 0.82 | PRMT1 (0.52) | PRMT1WDR5NQO2ALDH1A1TOP1 | |
| SCHEMBL14369773 | 0.81 | WDR5 (0.50) | PRMT1WDR5NQO2ALDH1A1TOP1 | |
| SCHEMBL8973334 | 0.79 | PRMT1 (0.59) | PRMT1WDR5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL24644767 | 0.79 | WDR5 (0.52) | PRMT1WDR5NQO2ALDH1A1TOP1 | |
| SCHEMBL8975885 | 0.79 | PRMT1 (0.46) | PRMT1WDR5NQO2 | |
| SCHEMBL8975569 | 0.78 | PRMT1 (0.63) | PRMT1WDR5NQO2ALDH1A1TOP1 | |
| SCHEMBL27438022 | 0.77 | WDR5 (0.53) | PRMT1WDR5NQO2ALDH1A1TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188121-B2 | Substituted pyridines as antiparasitic AZA teraryl compounds | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-05-29 | — | — | US | disclosed |
| US-20110257199-A1 | NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS | TIDWELL RICHARD R | 2011-10-20 | — | — | US | disclosed |
| US-7964619-B2 | Teraryl components as antiparasitic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-06-21 | — | — | US | disclosed |
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TPMT, TYMS, DDT | PRMT1 2351/4885WDR5 1295/4885NQO2 2112/4885 |
| US-20110257199-A1 | NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS | DDT, ZC3HAV1, MAVS | PRMT1 2522/4885WDR5 1227/4885NQO2 2186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.