Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Biguanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biguanide SCHEMBL4198353 | 0.97 | ACHE (0.40) | ACHECA2CA9LDHALDHB | |
| Biguanide SCHEMBL5489883 | 0.86 | — | — | |
| Biguanide SCHEMBL27267801 | 0.84 | FFAR3 (0.44) | ACHECA2CA9LDHALDHB | |
| Biguanide SCHEMBL28833765 | 0.84 | FFAR3 (0.44) | ACHECA2CA9LDHALDHB | |
| Bicarbonate SCHEMBL11151203 | 0.84 | CRBN (0.43) | ACHECA2CA9LDHALDHB | |
| Biguanide SCHEMBL27508171 | 0.84 | FFAR3 (0.44) | ACHECA2CA9LDHALDHB | |
| Biguanide SCHEMBL28444535 | 0.84 | FFAR3 (0.44) | ACHECA2CA9LDHALDHB | |
| Bicarbonate SCHEMBL2670830 | 0.84 | CRBN (0.43) | ACHECA2CA9LDHALDHB | |
| Biguanide SCHEMBL17701180 | 0.83 | LDHA (0.35) | ACHECA2CA9LDHALDHB | |
| Biguanide SCHEMBL28232006 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536482-A | Process for pollution control | NALCO FUEL TECH (US) | 1996-07-16 | — | — | US | disclosed |
| WO-1994008895-A1 | PROCESS AND COMPOSITION FOR POLLUTION CONTROL | NALCO FUEL TECH (US) | 1994-04-28 | — | — | WO | disclosed |