Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27524531 | 0.86 | PPARG (0.46) | AKT1KMT2APDE10AKDM4EALDH1A1 | |
| SCHEMBL27342003 | 0.84 | PPARG (0.53) | PDE10APTGS2 | |
| SCHEMBL1143252 | 0.80 | KDM4E (0.50) | HSD17B10KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL27965594 | 0.80 | CYP3A4 (0.50) | HSD17B10KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL8399022 | 0.80 | LMNA (0.50) | HSD17B10KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL29940384 | 0.80 | KDM4E (0.50) | HSD17B10KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL25629899 | 0.79 | CYP1A2 (0.50) | HSD17B10KMT2APDE10AKDM4EALDH1A1 | |
| Alpha-Naphthylacetate SCHEMBL28344940 | 0.79 | ALDH1A1 (0.60) | HSD17B10KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL27159137 | 0.78 | ABCB11 (0.49) | HSD17B10KMT2APDE10AKDM4EALDH1A1 | |
| SCHEMBL8985762 | 0.78 | CNR2 (0.49) | KMT2AKDM4EALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1060761-C | New aryl (alkyl) propylamides process for preparing them and pharmaceutical compositions containing them | ADIR ET COMPAGUIE (FR) | 2001-01-17 | — | — | CN | disclosed |
| EP-0711283-B1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER (US) | 1999-06-16 | — | — | EP | disclosed |
| US-5618811-A | Tetrahydro-1H-benzazepinones and hexahydroazepinones as selective cholecystokinin-B receptor antagonists | PFIZER INC. (US) | 1997-04-08 | — | — | US | disclosed |
| CN-1145897-A | New aryl (alkyl) propylamides process for preparing them and pharmaceutical compositions containing them | ADIR (FR) | 1997-03-26 | — | — | CN | disclosed |
| EP-0711283-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995003281-A1 | TETRAHYDRO-1H-BENZAZEPINONES AND HEXAHYDROAZEPINONES AS SELECTIVE CHOLECYSTOKININ-B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1995-02-02 | — | — | WO | disclosed |