Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 8/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 8/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974131 | 1.00 | PTGER4 (0.41) | PTGER4PTGER2PTGER3SMN1; SMN2PTGER1 | |
| SCHEMBL8973873 | 0.81 | MCL1 (0.51) | PTGER4SMN1; SMN2GAAKDM4EALDH1A1 | |
| SCHEMBL8974304 | 0.75 | PKM (0.50) | PTGER4PTGER2PTGER3SMN1; SMN2PTGER1 | |
| SCHEMBL8974308 | 0.75 | PKM (0.50) | PTGER4PTGER2PTGER3SMN1; SMN2PTGER1 | |
| SCHEMBL3340127 | 0.74 | PTGER3 (0.62) | PTGER4PTGER2PTGER3SMN1; SMN2PTGER1 | |
| SCHEMBL2292426 | 0.74 | PTGER3 (0.62) | PTGER4PTGER2PTGER3SMN1; SMN2PTGER1 | |
| SCHEMBL8974844 | 0.73 | PTGER4 (0.44) | PTGER4PTGER2PTGER3SMN1; SMN2KDM4E | |
| SCHEMBL8974902 | 0.73 | PTGER4 (0.44) | PTGER4PTGER2PTGER3SMN1; SMN2KDM4E | |
| SCHEMBL4653615 | 0.73 | KDM4E (0.51) | PTGER4PTGER2PTGER3SMN1; SMN2PTGER1 | |
| SCHEMBL4653617 | 0.73 | KDM4E (0.51) | PTGER4PTGER2PTGER3SMN1; SMN2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |