Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.69 |
| ▸ | CA9 | Q16790 | 9/20 | 0.69 |
| ▸ | CA12 | O43570 | 6/20 | 0.69 |
| ▸ | CA1 | P00915 | 5/20 | 0.69 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974347 | 0.85 | PTGS2 (0.62) | CA2CA9CA12CA1PTGS2 | |
| SCHEMBL8974581 | 0.83 | CA2 (0.57) | CA2CA9CA12CA1KMT2A | |
| SCHEMBL8974782 | 0.82 | CA2 (0.68) | CA2CA9CA12CA1CA4 | |
| SCHEMBL9117865 | 0.80 | CA2 (0.61) | CA2CA9CA12CA1CA4 | |
| SCHEMBL9130312 | 0.79 | CA9 (0.46) | CA2CA9CA12CA1PTGS2 | |
| SCHEMBL9114935 | 0.77 | PTGS2 (0.44) | CA2CA9CA12CA1CA4 | |
| SCHEMBL8658259 | 0.77 | CA2 (0.69) | CA2CA9CA12CA1CA4 | |
| SCHEMBL8973868 | 0.76 | CA2 (0.48) | CA2CA9CA12CA1CA4 | |
| SCHEMBL8974243 | 0.76 | CA2 (0.71) | CA2CA9CA12CA1CA4 | |
| SCHEMBL8974195 | 0.75 | CA9 (0.53) | CA2CA9CA12CA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |