Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974844 | 1.00 | PTGER4 (0.44) | PTGER4PTGER2PTGER3KDM4EALDH1A1 | |
| SCHEMBL8974220 | 0.84 | HPGD (0.49) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL8974227 | 0.84 | HPGD (0.49) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL8974298 | 0.84 | MCL1 (0.38) | KDM4EALDH1A1MAPT | |
| SCHEMBL8974484 | 0.84 | PTPN1 (0.36) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8974504 | 0.84 | PTPN1 (0.36) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8974519 | 0.84 | PTPN1 (0.36) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8974704 | 0.83 | PKM (0.48) | PTGER4PTGER2PTGER3KDM4EALDH1A1 | |
| SCHEMBL8974694 | 0.83 | PKM (0.48) | PTGER4PTGER2PTGER3KDM4EALDH1A1 | |
| SCHEMBL8973881 | 0.80 | PTPN1 (0.36) | KDM4EALDH1A1HPGDMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |