Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | PELI1 | Q96FA3 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974213 | 1.00 | HPGD (0.54) | HPGDTRPV1KDM4EALDH1A1KMT2A | |
| SCHEMBL8974227 | 0.85 | HPGD (0.49) | HPGDTRPV1KDM4EALDH1A1KMT2A | |
| SCHEMBL8974220 | 0.85 | HPGD (0.49) | HPGDTRPV1KDM4EALDH1A1KMT2A | |
| SCHEMBL8974704 | 0.82 | PKM (0.48) | HPGDKDM4EALDH1A1KMT2AAPP | |
| SCHEMBL8974694 | 0.82 | PKM (0.48) | HPGDKDM4EALDH1A1KMT2AAPP | |
| SCHEMBL8973812 | 0.76 | ERN1 (0.49) | — | |
| SCHEMBL10227975 | 0.74 | TRPV1 (0.64) | HPGDTRPV1KDM4EALDH1A1KMT2A | |
| SCHEMBL8973822 | 0.73 | ERN1 (0.37) | KDM4EALDH1A1KMT2APTGS2 | |
| SCHEMBL8974825 | 0.73 | ERN1 (0.37) | KDM4EALDH1A1KMT2APTGS2 | |
| SCHEMBL8973836 | 0.73 | ERN1 (0.37) | KDM4EALDH1A1KMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |