Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974220 | 1.00 | HPGD (0.49) | HPGDKDM4EALDH1A1APPTRPV1 | |
| SCHEMBL8974213 | 0.85 | HPGD (0.54) | HPGDKDM4EALDH1A1APPTRPV1 | |
| SCHEMBL8974205 | 0.85 | HPGD (0.54) | HPGDKDM4EALDH1A1APPTRPV1 | |
| SCHEMBL8974844 | 0.84 | PTGER4 (0.44) | HPGDKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL8974902 | 0.84 | PTGER4 (0.44) | HPGDKDM4EALDH1A1KMT2AMAPT | |
| SCHEMBL8974298 | 0.78 | MCL1 (0.38) | KDM4EALDH1A1L3MBTL1MAPTCYP2C19 | |
| SCHEMBL8974519 | 0.75 | PTPN1 (0.36) | KDM4EALDH1A1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL8974484 | 0.75 | PTPN1 (0.36) | KDM4EALDH1A1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL8974504 | 0.75 | PTPN1 (0.36) | KDM4EALDH1A1KMT2ASMN1; SMN2TDP1 | |
| SCHEMBL8973940 | 0.72 | MAPT (0.41) | ALDH1A1KMT2AL3MBTL1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |