Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974704 | 1.00 | PKM (0.48) | PKMPTGS1PTGS2KDM4EGAA | |
| SCHEMBL8973812 | 0.83 | ERN1 (0.49) | — | |
| SCHEMBL8974844 | 0.83 | PTGER4 (0.44) | KDM4EPTGER4PTGER3PTGER2MAPT | |
| SCHEMBL8974902 | 0.83 | PTGER4 (0.44) | KDM4EPTGER4PTGER3PTGER2MAPT | |
| SCHEMBL8974205 | 0.82 | HPGD (0.54) | PTGS2KDM4EKMT2AHPGDALDH1A1 | |
| SCHEMBL8974213 | 0.82 | HPGD (0.54) | PTGS2KDM4EKMT2AHPGDALDH1A1 | |
| SCHEMBL8973822 | 0.82 | ERN1 (0.37) | PTGS1PTGS2KDM4EGAAMAPT | |
| SCHEMBL8973836 | 0.82 | ERN1 (0.37) | PTGS1PTGS2KDM4EGAAMAPT | |
| SCHEMBL8974825 | 0.82 | ERN1 (0.37) | PTGS1PTGS2KDM4EGAAMAPT | |
| SCHEMBL9655192 | 0.81 | PSEN1 (0.36) | PKMPTGS1PTGS2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |