Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 7/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9119214 | 0.81 | PTGS2 (0.52) | PTGS2EPHX2LRRK2CCR6PTGS1 | |
| SCHEMBL8974819 | 0.80 | PTGS2 (0.56) | PTGS2PTGS1FYNMAP4K4MINK1 | |
| SCHEMBL8974143 | 0.80 | PTGS2 (0.63) | PTGS2PTGS1GPR119 | |
| SCHEMBL8973804 | 0.79 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL8974293 | 0.79 | PTGS2 (0.45) | PTGS2PTGS1MAP4K4MINK1 | |
| SCHEMBL8655043 | 0.78 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL8974448 | 0.78 | PTGS2 (0.48) | PTGS2LRRK2CCR6GPR119 | |
| SCHEMBL8973855 | 0.78 | KCNH2 (0.55) | PTGS2PTGS1MAP4K4MINK1 | |
| SCHEMBL561798 | 0.77 | SLC40A1 (0.46) | PTGS2EPHX2LRRK2 | |
| SCHEMBL8388632 | 0.76 | PTGS2 (0.60) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |