Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CCR6 | P51684 | 3/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974590 | 0.93 | PTGS2 (0.48) | PTGS2GPR119ATRMLNRKDM1A | |
| SCHEMBL8974324 | 0.88 | CA2 (0.52) | PTGS2CCR6MLNRKDM1A | |
| SCHEMBL8974143 | 0.85 | PTGS2 (0.63) | PTGS2GPR119 | |
| SCHEMBL8974082 | 0.82 | CA2 (0.52) | PTGS2MLNRKDM1A | |
| SCHEMBL9116993 | 0.82 | PTGS2 (0.54) | PTGS2GPR119ATRKDM4EALDH1A1 | |
| SCHEMBL8974359 | 0.82 | PTGS2 (0.55) | PTGS2GPR119 | |
| SCHEMBL8974116 | 0.81 | PTGS2 (0.44) | PTGS2GPR119 | |
| SCHEMBL8974412 | 0.81 | PTGS2 (0.48) | PTGS2GPR119 | |
| SCHEMBL9117705 | 0.80 | PTGS2 (0.49) | PTGS2GPR119ATRKDM4EALDH1A1 | |
| SCHEMBL8973819 | 0.79 | PTGS2 (0.46) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| WO-1995030656-A1 | SUBSTITUTED CYCLOPENTADIENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |