Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31067110 | 0.84 | PTGS2 (0.40) | ALDH1A1HSD17B10ENPP1NPC1RAB9A | |
| SCHEMBL26556671 | 0.83 | CYP2A6 (0.62) | CYP2A6ALDH1A1HSD17B10MAPK1HPGD | |
| SCHEMBL28755844 | 0.82 | CYP2A6 (0.44) | CYP2A6HPGDMEN1KMT2ACYP1A2 | |
| SCHEMBL31067139 | 0.81 | PDK2 (0.38) | ALDH1A1MEN1NPC1KMT2ANFE2L2 | |
| SCHEMBL20898317 | 0.81 | PDK2 (0.38) | ALDH1A1MEN1NPC1KMT2ANFE2L2 | |
| SCHEMBL31067144 | 0.81 | TAAR1 (0.42) | CTSAALDH1A1MAPK1HPGDMEN1 | |
| SCHEMBL10091222 | 0.81 | MEN1 (0.42) | CTSAHSD17B10HPGDENPP1MEN1 | |
| SCHEMBL3538299 | 0.81 | CTSA (0.33) | CYP2A6CTSACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20777596 | 0.81 | NPC1 (0.47) | HTTMAPK1HPGDENPP1MEN1 | |
| SCHEMBL5271966 | 0.80 | CYP2A6 (0.59) | CYP2A6ALDH1A1HSD17B10MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5540838-A | Stimulation of microbial para-dechlorination of polychlorinated biphenyls | GENERAL ELECTRIC COMPANY (US) | 1996-07-30 | — | — | US | claimed |
| US-12012466-B2 | Peptide macrocycles against Acinetobacter baumannii | HOFFMANN-LA ROCHE INC. (US) | 2024-06-18 | — | — | US | disclosed |
| CN-110366556-B | Antibacterial peptide macrocyclic compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2024-01-05 | — | — | CN | disclosed |
| US-20220411468-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | HOFFMANN-LA ROCHE INC. (US) | 2022-12-29 | — | — | US | disclosed |
| EP-3609904-B1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-11-30 | — | — | EP | disclosed |
| CN-108350028-B | Peptide macrocycles against Acinetobacter baumannii | 豪夫迈·罗氏有限公司 | 2021-12-07 | — | — | CN | disclosed |
| US-11066443-B2 | Anti-bacterial peptide macrocycles and use thereof | HOFFMANN-LA ROCHE INC. (US) | 2021-07-20 | — | — | US | disclosed |
| US-20210094914-A1 | HETEROCYCLIC COMPOUND, ORGANIC LIGHT EMITTING DIODE COMPRISING SAME, MANUFACTURING METHOD THEREFOR, AND COMPOSITION FOR ORGANIC LAYER | LT MATERIALS CO., LTD. (KR) | 2021-04-01 | — | — | US | disclosed |
| EP-3368544-B1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | HOFFMANN LA ROCHE (CH) | 2020-06-17 | — | — | EP | disclosed |
| EP-3609904-A1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | H. Hoffnabb-La Roche Ag (CH) | 2020-02-19 | — | — | EP | disclosed |
| US-20200040031-A1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | HOFFMANN LA ROCHE (US) | 2020-02-06 | — | — | US | disclosed |
| US-20180362578-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | HOFFMANN-LA ROCHE INC. (US) | 2018-12-20 | — | — | US | disclosed |
| WO-2018189065-A1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2018-10-18 | — | — | WO | disclosed |
| EP-3388444-A1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2018-10-17 | — | — | EP | disclosed |
| EP-3368544-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | H. Hoffnabb-La Roche Ag (CH) | 2018-09-05 | — | — | EP | disclosed |
| US-10030047-B2 | Peptide macrocycles against acinetobacter baumannii | HOFFMANN-LA ROCHE INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-20170233437-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | HOFFMANN-LA ROCHE INC. (US) | 2017-08-17 | — | — | US | disclosed |
| WO-2017072062-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | F. HOFFMANN-LA ROCHE AG (CH) | 2017-05-04 | — | — | WO | disclosed |
| US-5540838-A | Stimulation of microbial para-dechlorination of polychlorinated biphenyls | GENERAL ELECTRIC COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| US-5540838-A | Stimulation of microbial para-dechlorination of polychlorinated biphenyls | GENERAL ELECTRIC COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11066443-B2 | Anti-bacterial peptide macrocycles and use thereof | CFTR, VIP, NGLY1 | CYP2A6 4703/4885CTSA 264/4885HTT 2536/4885 |
| US-20220411468-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | VIP, ARG1, CX3CR1 | CYP2A6 3633/4885CTSA 1716/4885HTT 4717/4885 |
| US-12012466-B2 | Peptide macrocycles against Acinetobacter baumannii | VIP, ARG1, CX3CR1 | CYP2A6 3633/4885CTSA 1716/4885HTT 4717/4885 |
| US-20200040031-A1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | CFTR, VIP, NGLY1 | CYP2A6 4703/4885CTSA 264/4885HTT 2536/4885 |
| US-20180362578-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | VIP, ARG1, CX3CR1 | CYP2A6 3633/4885CTSA 1716/4885HTT 4717/4885 |
| US-20170233437-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | VIP, ARG1, CX3CR1 | CYP2A6 3633/4885CTSA 1716/4885HTT 4717/4885 |
| US-10030047-B2 | Peptide macrocycles against acinetobacter baumannii | VIP, ARG1, CX3CR1 | CYP2A6 3633/4885CTSA 1716/4885HTT 4717/4885 |
| US-20210094914-A1 | HETEROCYCLIC COMPOUND, ORGANIC LIGHT EMITTING DIODE COMPRISING SAME, MANUFACTURING METHOD THEREFOR, AND COMPOSITION FOR ORGANIC LAYER | CYP1B1, NOTUM, FAR1 | CYP2A6 192/4885CTSA 4667/4885HTT 1251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.