Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974149 | 0.84 | KDM4E (0.38) | MAPTL3MBTL1SMN1; SMN2MAPK1GAA | |
| SCHEMBL10456520 | 0.83 | L3MBTL1 (0.38) | MAPTL3MBTL1TDP1GAADRD2 | |
| SCHEMBL8974496 | 0.81 | MCHR1 (0.41) | MAPTL3MBTL1TDP1GAAHPGD | |
| SCHEMBL9025097 | 0.80 | HTR1A (0.47) | SMN1; SMN2BCHEHTR1AABCB1ADRA1D | |
| SCHEMBL9025081 | 0.77 | L3MBTL1 (0.39) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL27312982 | 0.77 | ERN1 (0.40) | NPC1RAB9AMAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL10456565 | 0.76 | PTPN1 (0.35) | — | |
| SCHEMBL8974775 | 0.74 | SMN1; SMN2 (0.36) | MAPTSMN1; SMN2MAPK1GAABCHE | |
| SCHEMBL8974801 | 0.74 | GAA (0.36) | NPC1RAB9AL3MBTL1TDP1GAA | |
| SCHEMBL23041327 | 0.73 | MAPT (0.58) | MAPTL3MBTL1MAPK1TDP1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |