Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974775 | 0.89 | SMN1; SMN2 (0.36) | KDM4EGAARECQLSMN1; SMN2ALDH1A1 | |
| SCHEMBL10456520 | 0.87 | L3MBTL1 (0.38) | KDM4EGAARECQLPTPN1L3MBTL1 | |
| SCHEMBL8974496 | 0.85 | MCHR1 (0.41) | GAAPTPN1L3MBTL1MTNR1AMEN1 | |
| SCHEMBL10456778 | 0.84 | SMN1; SMN2 (0.46) | KDM4EGAASMN1; SMN2PTPN1L3MBTL1 | |
| SCHEMBL8974402 | 0.84 | NPC1 (0.41) | GAASMN1; SMN2L3MBTL1MAPK1MAPT | |
| SCHEMBL9025097 | 0.83 | HTR1A (0.47) | SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL8974841 | 0.83 | SMN1; SMN2 (0.41) | KDM4EGAARECQLSMN1; SMN2L3MBTL1 | |
| SCHEMBL10456565 | 0.82 | PTPN1 (0.35) | PTPN1KMT2A | |
| SCHEMBL8974780 | 0.82 | PTPN1 (0.46) | KDM4EGAASMN1; SMN2PTPN1L3MBTL1 | |
| SCHEMBL8974801 | 0.80 | GAA (0.36) | GAAPTPN1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |