Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN2 | Q9H2S1 | 5/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11926107 | 0.84 | PTPN1 (0.41) | CYP1A2CYP3A4MEN1RECQLKMT2A | |
| SCHEMBL13391679 | 0.80 | LPAR1 (0.43) | KCNN2KCNN3CYP1A2CYP3A4MEN1 | |
| SCHEMBL1446331 | 0.80 | KMT2A (0.51) | CYP1A2CYP3A4MEN1CYP2C9CYP2C19 | |
| SCHEMBL8974681 | 0.75 | KDM4E (0.39) | MEN1RECQLKMT2AL3MBTL1ELANE | |
| SCHEMBL30676967 | 0.74 | PTPN1 (0.40) | CYP1A2CYP3A4MEN1CYP2C9CYP2C19 | |
| SCHEMBL9170583 | 0.73 | GABRA1 (0.52) | KCNN2KCNN3CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8974556 | 0.72 | ELANE (0.39) | MEN1RECQLKMT2AELANEPTPN1 | |
| SCHEMBL25536876 | 0.72 | KCNN4 (0.34) | CYP1A2CYP3A4MEN1KMT2AL3MBTL1 | |
| SCHEMBL30033709 | 0.72 | KCNN4 (0.34) | CYP1A2CYP3A4MEN1KMT2AL3MBTL1 | |
| SCHEMBL22914881 | 0.72 | ADRB2 (0.48) | CYP1A2MEN1CYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| CN-1027064-C | Naphthalene derivatives | EISAI CO LTD (JP) | 1994-12-21 | — | — | CN | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| CN-1043696-A | NAPHTHALENE DERIVATIVES | EISAI CO LTD (JP) | 1990-07-11 | — | — | CN | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |