Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRK6 | P43250 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974556 | 0.87 | ELANE (0.39) | KDM4EGAARECQLPTPN1ELANE | |
| SCHEMBL11926107 | 0.85 | PTPN1 (0.41) | KDM4EGAARECQLPTPN1MAPT | |
| SCHEMBL22967810 | 0.82 | KDM4E (0.50) | KDM4EGAARECQLL3MBTL1MAPT | |
| SCHEMBL8974758 | 0.81 | SMN1; SMN2 (0.35) | KDM4EGAARECQLPTPN1L3MBTL1 | |
| SCHEMBL9024611 | 0.81 | HRH1 (0.43) | L3MBTL1HPGDLMNA | |
| SCHEMBL8973880 | 0.80 | ALOX5 (0.37) | KDM4EGAARECQLPTPN1 | |
| SCHEMBL8974149 | 0.80 | KDM4E (0.38) | KDM4EGAARECQLPTPN1L3MBTL1 | |
| SCHEMBL27655777 | 0.80 | L3MBTL1 (0.58) | KDM4EPTPN1L3MBTL1MAPTNPSR1 | |
| SCHEMBL13791138 | 0.79 | PTPN1 (0.44) | KDM4EPTPN1L3MBTL1MAPTNPSR1 | |
| SCHEMBL25893410 | 0.79 | PARP15 (0.38) | KDM4EGAARECQLL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| CN-1027064-C | Naphthalene derivatives | EISAI CO LTD (JP) | 1994-12-21 | — | — | CN | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| CN-1043696-A | NAPHTHALENE DERIVATIVES | EISAI CO LTD (JP) | 1990-07-11 | — | — | CN | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |