Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 4/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9117705 | 0.95 | PTGS2 (0.49) | PTGS2PTGS1GPR119ATRCCR6 | |
| SCHEMBL9117672 | 0.93 | PTGS2 (0.51) | PTGS2PTGS1GPR119ATRCCR6 | |
| SCHEMBL9117491 | 0.89 | PTGS2 (0.46) | PTGS2PTGS1GPR119ATRCCR6 | |
| SCHEMBL9116434 | 0.89 | PTGS2 (0.46) | PTGS2PTGS1GPR119ATRCCR6 | |
| SCHEMBL9115957 | 0.88 | CA2 (0.49) | PTGS2PTGS1CCR6 | |
| SCHEMBL9118956 | 0.84 | CA2 (0.47) | PTGS2PTGS1CCR6 | |
| SCHEMBL9115333 | 0.84 | CA2 (0.47) | PTGS2PTGS1CCR6 | |
| SCHEMBL9117633 | 0.84 | CA2 (0.49) | PTGS2PTGS1ATRCCR6 | |
| SCHEMBL9117836 | 0.83 | PTGS2 (0.59) | PTGS2PTGS1GPR119 | |
| SCHEMBL8974448 | 0.82 | PTGS2 (0.48) | PTGS2GPR119ATRCCR6LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030652-A1 | SUBSTITUTED SPIRODIENES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-11-16 | — | — | WO | disclosed |