Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.62 |
| ▸ | CA2 | P00918 | 8/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.52 |
| ▸ | CA1 | P00915 | 7/20 | 0.52 |
| ▸ | CA12 | O43570 | 7/20 | 0.52 |
| ▸ | CA9 | Q16790 | 6/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8974079 | 0.87 | KIF11 (0.64) | KIF11CA2PTGS2CA1CA12 | |
| SCHEMBL8974259 | 0.87 | KIF11 (0.47) | KIF11CA2PTGS2CA1CA12 | |
| SCHEMBL8974646 | 0.87 | KIF11 (0.47) | KIF11CA2PTGS2CA1CA12 | |
| SCHEMBL8974522 | 0.86 | PTGS2 (0.52) | KIF11PTGS2PTGS1 | |
| SCHEMBL8974445 | 0.86 | KIF11 (0.62) | KIF11CA2PTGS2CA1CA12 | |
| SCHEMBL8974523 | 0.84 | KIF11 (0.42) | KIF11CA2PTGS2CA1CA12 | |
| SCHEMBL8973747 | 0.84 | PTGS2 (0.55) | CA2PTGS2CA1CA12CA9 | |
| SCHEMBL8974637 | 0.82 | KIF11 (0.70) | KIF11CA2PTGS2CA1CA12 | |
| SCHEMBL8974190 | 0.82 | KIF11 (0.40) | KIF11CA2PTGS2CA1CA12 | |
| SCHEMBL8974109 | 0.81 | KIF11 (0.68) | KIF11CA2PTGS2CA1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5576339-A | Pyridyl substituted cyclopentadienes for the treatment of inflamation | HUANG HORNG-CHIH (US) | 1996-11-19 | — | — | US | disclosed |
| US-5418254-A | Side effect reduction | G. D. SEARLE & CO. (US) | 1995-05-23 | — | — | US | disclosed |