SCHEMBL8974765

SCHEMBL8974765

Fc1cc(C(Cl)(Cl)Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11553083 0.81 CYP3A4 (0.42) CYP3A4TSHRMAPK1TDP1
SCHEMBL8038010 0.79 CYP3A4 (0.31) CYP3A4TSHRMAPK1TDP1
SCHEMBL8525893 0.78 CYP3A4 (0.33) CYP3A4TSHRMAPK1TDP1
SCHEMBL5361253 0.76
SCHEMBL29726331 0.76
SCHEMBL8664294 0.75 TSHR (0.44) CYP3A4TSHRMAPK1TDP1
SCHEMBL9358268 0.74 CYP3A4 (0.41) CYP3A4TSHR
SCHEMBL6417699 0.74 CYP3A4 (0.53) CYP3A4TSHRMAPK1TDP1
SCHEMBL8530933 0.73 CYP3A4 (0.33) CYP3A4TSHRMAPK1TDP1
SCHEMBL7057611 0.72 TSHR (0.46) CYP3A4TSHRMAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0431373-B1 Processes for producing 5-fluorbenzoic acids and their intermediates ASAHI GLASS CO LTD (JP) 1996-04-10 EP claimed
EP-0431373-A2 Processes for producing 5-fluorbenzoic acids and their intermediates ASAHI GLASS COMPANY LTD. (JP) 1991-06-12 EP claimed
JP-7165638-A None JP disclosed
EP-0431373-B1 Processes for producing 5-fluorbenzoic acids and their intermediates ASAHI GLASS CO LTD (JP) 1996-04-10 EP disclosed
JP-H07165638-A NEW FLUOROBENZOTRICHLORIDE COMPOUND ASAHI GLASS CO LTD 1995-06-27 JP disclosed
US-5332851-A Trichloromethylating a fluorodihalobenzene, reaction with ammonia, hydrolysis of the nitrile ASAHI GLASS COMPANY LTD. (JP) 1994-07-26 US disclosed
EP-0583705-A1 Process for the preparation of 2,3,4-trichloro-5-fluoro-benzoylchloride BAYER AG (DE) 1994-02-23 EP disclosed
US-5241111-A Trichloromethylating a fluorobenzene, reacting with aqueous ammonia, fluorinating, hydrolyzing ASAHI GLASS COMPANY LTD. (JP) 1993-08-31 US disclosed
EP-0431373-A2 Processes for producing 5-fluorbenzoic acids and their intermediates ASAHI GLASS COMPANY LTD. (JP) 1991-06-12 EP disclosed