Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10456778 | 0.87 | SMN1; SMN2 (0.46) | PTPN1SMN1; SMN2MAPTGAAL3MBTL1 | |
| SCHEMBL8974149 | 0.82 | KDM4E (0.38) | PTPN1SMN1; SMN2MAPTGAAL3MBTL1 | |
| SCHEMBL9025097 | 0.80 | HTR1A (0.47) | SMN1; SMN2ALDH1A1POLBHTR1AADRA1D | |
| SCHEMBL8974775 | 0.80 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPTGAAALDH1A1KDM4E | |
| SCHEMBL8974841 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTGAAL3MBTL1RAB9A | |
| SCHEMBL31459762 | 0.76 | MAPT (0.55) | SMN1; SMN2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL28586196 | 0.75 | SMN1; SMN2 (0.65) | PTPN1SMN1; SMN2MAPTGAAL3MBTL1 | |
| SCHEMBL13594738 | 0.73 | PTPN1 (0.61) | PTPN1ALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL8974794 | 0.73 | PTPN1 (0.44) | PTPN1MAPTGAAL3MBTL1RAB9A | |
| SCHEMBL13409419 | 0.72 | CA12 (0.46) | SMN1; SMN2MAPTGAAL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527948-A | SUBSTITUTED NAPHTHYL-ALKENOIC ACIDS FOR TREATING AUTOIMMUNE DISORDERS | EISAI CORP. LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5298649-A | Antiinflammatory agents, rheumatic agents and treatment of autoimmune diseases | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0376288-B1 | Naphthalene derivative | EISAI CO LTD (JP) | 1994-03-09 | — | — | EP | disclosed |
| US-5134111-A | Inhibitors of interleukin-1 as antiinflammatory agents | EISAI CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0376288-A1 | Naphthalene derivative | Eisai Co., Ltd. (JP) | 1990-07-04 | — | — | EP | disclosed |