Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728588 | 0.88 | NFE2L2 (0.43) | NFE2L2HSD11B1GRIK1GRIK2TAAR1 | |
| SCHEMBL10423140 | 0.82 | NFE2L2 (0.50) | NFE2L2HSD11B1GRIK1GRIK2APP | |
| SCHEMBL17862090 | 0.81 | NFE2L2 (0.59) | NFE2L2HSD11B1APPPTGS1FBP1 | |
| SCHEMBL8325205 | 0.78 | AHR (0.45) | NFE2L2GRIK1GRIK2TAAR1PTGS1 | |
| SCHEMBL5682382 | 0.78 | AHR (0.45) | NFE2L2GRIK1GRIK2TAAR1PTGS1 | |
| SCHEMBL7423750 | 0.78 | NFE2L2 (0.46) | NFE2L2HSD11B1APPPTGS1FBP1 | |
| SCHEMBL9663338 | 0.78 | NFE2L2 (0.46) | NFE2L2HSD11B1APPPTGS1FBP1 | |
| SCHEMBL7097687 | 0.78 | HSD11B1 (0.47) | NFE2L2HSD11B1GRIK1GRIK2APP | |
| SCHEMBL7097682 | 0.78 | HSD11B1 (0.47) | NFE2L2HSD11B1GRIK1GRIK2APP | |
| SCHEMBL8325852 | 0.78 | NFE2L2 (0.45) | NFE2L2GRIK1GRIK2TAAR1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023076218-A1 | SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-05-04 | — | — | WO | disclosed |
| US-5543400-A | ANTIBIOTICS | ROUSSEL UCLAF (FR) | 1996-08-06 | — | — | US | disclosed |
| EP-0606024-B1 | Erythromycin derivatives, their process of preparation and their application as medicaments | ROUSSEL UCLAF (FR) | 1996-03-20 | — | — | EP | disclosed |
| EP-0606024-A1 | Erythromycin derivatives, their process of preparation and their application as medicaments | ROUSSEL UCLAF (FR) | 1994-07-13 | — | — | EP | disclosed |