Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27916823 | 0.81 | MAPK1 (0.54) | MAPK1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL28684444 | 0.79 | L3MBTL1 (0.57) | MAPK1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL28421674 | 0.78 | ALDH1A1 (0.51) | MAPK1TDP1MAPTKMT2AMEN1 | |
| Benzene SCHEMBL28690163 | 0.76 | MAPK1 (0.58) | MAPK1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL7085528 | 0.76 | MAPK1 (0.58) | MAPK1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL571114 | 0.76 | TDP1 (0.58) | MAPK1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL28587168 | 0.75 | L3MBTL1 (0.49) | MAPK1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL28686513 | 0.75 | KMT2A (0.47) | MAPK1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL22313390 | 0.74 | CES1 (0.56) | MAPK1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL136826 | 0.74 | CES1 (0.56) | MAPK1TDP1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543919-B1 | USE OF HETEROCYCLIC AMINO-ALCOHOL COMPOUNDS IN THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF CNS DISEASES | SEARLE & CO (US) | 1996-04-10 | — | — | EP | claimed |