Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL4626626 | 0.96 | — | — | |
| Ethylenediamine SCHEMBL9766852 | 0.92 | ALDH1A1 (0.77) | ALDH1A1TSHRMAPK1OPRM1TRPV1 | |
| Hydrazine SCHEMBL9665685 | 0.92 | — | — | |
| SCHEMBL757716 | 0.88 | — | — | |
| SCHEMBL1773428 | 0.88 | — | — | |
| SCHEMBL175732 | 0.88 | ALDH1A1 (1.00) | ALDH1A1TSHRMAPK1OPRM1 | |
| SCHEMBL27327 | 0.88 | — | — | |
| SCHEMBL7936337 | 0.84 | — | — | |
| SCHEMBL9324790 | 0.84 | ALDH1A1 (0.91) | ALDH1A1TSHRMAPK1OPRM1 | |
| Ammonia Solution, Strong SCHEMBL9250838 | 0.84 | ALDH1A1 (0.91) | ALDH1A1TSHRMAPK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705287-A1 | POLYUREAURETHANE PRIMERLESS STRUCTURAL ADHESIVE | ASHLAND OIL, INC. (US) | 1996-04-10 | — | — | EP | disclosed |
| EP-0705287-A4 | POLYUREAURETHANE PRIMERLESS STRUCTURAL ADHESIVE | ASHLAND OIL INC (US) | 1995-06-20 | — | — | EP | disclosed |