Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | ACR | P10323 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9780932 | 0.84 | KMT2A (0.43) | CYP2D6MAPK1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL22089696 | 0.83 | CYP2D6 (0.47) | CYP2D6MAPK1SNCAPRSS1ACR | |
| SCHEMBL22090243 | 0.83 | CYP2D6 (0.47) | CYP2D6MAPK1SNCAPRSS1ACR | |
| SCHEMBL715065 | 0.83 | CYP2D6 (0.47) | CYP2D6MAPK1SNCAPRSS1ACR | |
| SCHEMBL22089693 | 0.83 | CYP2D6 (0.47) | CYP2D6MAPK1SNCAPRSS1ACR | |
| SCHEMBL5671105 | 0.82 | KMT2A (0.45) | CYP2D6MAPK1PRSS1ACRALDH1A1 | |
| D-Alanine SCHEMBL3725637 | 0.82 | SLC1A3 (0.51) | CYP2D6MAPK1SLC1A3SLC1A2SLC1A1 | |
| Alanine SCHEMBL3254315 | 0.82 | SLC1A3 (0.51) | CYP2D6MAPK1SLC1A3SLC1A2SLC1A1 | |
| Alanine SCHEMBL723059 | 0.82 | SLC1A3 (0.51) | CYP2D6MAPK1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL31504465 | 0.80 | ALDH1A1 (0.50) | CYP2D6MAPK1SNCAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527919-A | Process for the preparation of 1-[(1,1'-biphenyl]-4-YL]-methyl-1H-imidazole-5-carboxylic acids | ROUSSEL UCLAF (FR) | 1996-06-18 | — | — | US | disclosed |