SCHEMBL8976464

SCHEMBL8976464

COC(=O)c1c(OC)cc2c(c1C)C(=O)c1c(OC)ccc(OC)c1C2=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.46
MEN1 O00255 5/20 0.46
KMT2A Q03164 5/20 0.46
ALDH1A1 P00352 5/20 0.46
KDM4E B2RXH2 3/20 0.46
USP2 O75604 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
DUSP3 P51452 1/20 0.46
MAPK1 P28482 4/20 0.40
HPGD P15428 3/20 0.40
HSD17B10 Q99714 3/20 0.40
RAB9A P51151 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
S1PR4 O95977 1/20 0.40
HSP90AA1 P07900 1/20 0.40
G6PD P11413 1/20 0.40
S1PR1 P21453 1/20 0.40
OPRK1 P41145 1/20 0.40
HTT P42858 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19452223 0.82 EPHX2 (0.48) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL13317458 0.82 SLC37A4 (0.58) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL19449184 0.82 ELANE (0.60) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL8976225 0.81 PRKCZ (0.47) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL16225976 0.77 EGFR (0.56) MEN1KMT2AEGFRPIM1FGFR1
SCHEMBL8976457 0.75 MAPT (0.55) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL2957671 0.75 MAPT (0.44) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL2958068 0.75 ELANE (0.49) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL16226654 0.74 SLC37A4 (0.56) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL25550056 0.73 CA12 (0.44) MAPTALDH1A1KDM4ETDP1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5424421-A Synthesis of carminic acid and principal intermediates EUROPEAN COLOUR PLC (GB) 1995-06-13 US claimed
EP-0602027-B1 SYNTHESIS OF CARMINIC ACID AND PRINCIPAL INTERMEDIATES EUROP COLOUR PLC (GB) 1996-03-27 EP disclosed
US-5424421-A Synthesis of carminic acid and principal intermediates EUROPEAN COLOUR PLC (GB) 1995-06-13 US disclosed
EP-0602027-A1 SYNTHESIS OF CARMINIC ACID AND PRINCIPAL INTERMEDIATES. EUROP COLOUR PLC (GB) 1994-06-22 EP disclosed
WO-1992001664-A1 SYNTHESIS OF CARMINIC ACID AND PRINCIPAL INTERMEDIATES EUROPEAN COLOUR PLC (GB) 1992-02-06 WO disclosed