SCHEMBL8976225

SCHEMBL8976225

COc1cc2c(c(C)c1C(=O)OCc1ccccc1)C(=O)c1c(OC)ccc(OC)c1C2=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCZ Q05513 1/20 0.47
SLC37A4 O43826 1/20 0.45
KMT2A Q03164 4/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
TDP1 Q9NUW8 3/20 0.43
MEN1 O00255 2/20 0.43
ALDH1A1 P00352 2/20 0.43
MAPT P10636 2/20 0.43
RXFP1 Q9HBX9 1/20 0.43
KDM4E B2RXH2 1/20 0.43
USP2 O75604 1/20 0.43
DUSP3 P51452 1/20 0.43
POLB P06746 1/20 0.43
NPC1 O15118 3/20 0.42
RAB9A P51151 3/20 0.42
LMNA P02545 1/20 0.42
PRNP P04156 1/20 0.42
PDE1C Q14123 1/20 0.42
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8976464 0.81 MAPT (0.46) SLC37A4KMT2ASMN1; SMN2TDP1MEN1
SCHEMBL8976187 0.79 TDP1 (0.44) SLC37A4KMT2ASMN1; SMN2TDP1MEN1
SCHEMBL31643516 0.77 TDP1 (0.49) PRKCZKMT2ASMN1; SMN2TDP1MEN1
SCHEMBL8976163 0.77 TACR2 (0.39) KMT2AMEN1POLB
SCHEMBL8976444 0.75 PRKCZ (0.45) PRKCZKMT2ASMN1; SMN2TDP1MEN1
SCHEMBL31643711 0.73 PRKCZ (0.45) PRKCZKMT2ASMN1; SMN2TDP1MEN1
SCHEMBL31638890 0.73 CA12 (0.52) PRKCZKMT2ASMN1; SMN2TDP1MEN1
SCHEMBL17652769 0.72 PRKCZ (0.57) PRKCZKMT2ATDP1MEN1ALDH1A1
SCHEMBL27638666 0.72 KMT2A (0.61) PRKCZKMT2ATDP1MEN1ALDH1A1
SCHEMBL2957671 0.71 MAPT (0.44) SLC37A4KMT2ASMN1; SMN2TDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0602027-B1 SYNTHESIS OF CARMINIC ACID AND PRINCIPAL INTERMEDIATES EUROP COLOUR PLC (GB) 1996-03-27 EP disclosed
US-5424421-A Synthesis of carminic acid and principal intermediates EUROPEAN COLOUR PLC (GB) 1995-06-13 US disclosed
EP-0602027-A1 SYNTHESIS OF CARMINIC ACID AND PRINCIPAL INTERMEDIATES. EUROP COLOUR PLC (GB) 1994-06-22 EP disclosed
WO-1992001664-A1 SYNTHESIS OF CARMINIC ACID AND PRINCIPAL INTERMEDIATES EUROPEAN COLOUR PLC (GB) 1992-02-06 WO disclosed