SCHEMBL8976520

SCHEMBL8976520

CC1(C)CCC(c2ccc(F)cc2)=CC1=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 5/20 0.35
PTGS2 P35354 5/20 0.35
ALDH1A1 P00352 2/20 0.34
POLB P06746 1/20 0.34
DRD2 P14416 2/20 0.33
SIGMAR1 Q99720 2/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
HCAR3 P49019 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
PGR P06401 1/20 0.33
ALPL P05186 1/20 0.33
HSD11B1 P28845 1/20 0.33
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8976063 0.82 ALDH1A1 (0.37) PTGS1PTGS2ALDH1A1POLBSIGMAR1
SCHEMBL8996595 0.82 SMN1; SMN2 (0.40) PTGS2ALDH1A1NPC1RAB9A
SCHEMBL7973057 0.69 HSD11B1 (0.36) PTGS1ALDH1A1NPC1RAB9AHSD11B1
SCHEMBL20374588 0.68 NPC1 (0.70) PTGS1PTGS2ALDH1A1NPC1RAB9A
SCHEMBL959235 0.66 CYP19A1 (0.33)
SCHEMBL16322256 0.66 CYP19A1 (0.33)
SCHEMBL3519376 0.66 MAPK14 (0.41) PTGS1PTGS2ALDH1A1HSD11B1
SCHEMBL16321921 0.65 POLB (0.33) POLB
SCHEMBL31668778 0.65 CYP19A1 (0.32) ALDH1A1
SCHEMBL4329065 0.65 CYP19A1 (0.32) RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5571831-A FUNGICIDE, AROMATASE INHIBITOR, ANTITUMOR KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-11-05 US disclosed
US-5547973-A AZOLE MODIFIED CYCLOHEXANOL; ANTITUMOR AGENT KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-08-20 US disclosed
US-5508298-A ADMINISTERING AS ANTITUMOR AGENT KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-04-16 US disclosed
US-5489597-A 2,2-DIMETHYL-5-HALOPHENYL-1-(1H,-1,2,4-TRIAZOLE-1-YLMETHYL) -CYCLOHEXANE-1-OL OR A SALT THEREOF FUNGICIDES KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1996-02-06 US disclosed
EP-0621268-A1 NOVEL AZOLE DERIVATIVE, PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITION KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) 1994-10-26 EP disclosed