SCHEMBL8976855

SCHEMBL8976855

Cc1cc(C(C)(C)C)c(OP2N(c3ccccc3)P(Oc3c(C(C)(C)C)cc(C)cc3C(C)(C)C)N2c2ccccc2)c(C(C)(C)C)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.35
POLB P06746 2/20 0.35
CA2 P00918 1/20 0.35
TYR P14679 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
TSHR P16473 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP2C19 P33261 1/20 0.31
TNFRSF1A P19438 1/20 0.31
LMNA P02545 1/20 0.30
MAPT P10636 1/20 0.30
BLM P54132 1/20 0.30
ATM Q13315 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
HSPA5 P11021 1/20 0.30
ADORA2A P29274 1/20 0.30
ADORA1 P30542 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8976846 0.88 CYP1A2 (0.35) ALDH1A1POLBCYP3A4TSHRCYP1A2
SCHEMBL8977017 0.75 SMN1; SMN2 (0.41) ALDH1A1POLBCA2TYRSMN1; SMN2
SCHEMBL8977041 0.75 GAA (0.40) ALDH1A1SMN1; SMN2TSHRLMNA
SCHEMBL8976801 0.73 APEX1 (0.37) ALDH1A1CA2CYP3A4TSHRCYP1A2
SCHEMBL11799450 0.70 ALDH1A1 (0.36) ALDH1A1POLBCA2TYRSMN1; SMN2
SCHEMBL10789897 0.67 SMN1; SMN2 (0.43) ALDH1A1POLBCA2TYRSMN1; SMN2
SCHEMBL10904840 0.67 SMN1; SMN2 (0.43) ALDH1A1POLBCA2TYRSMN1; SMN2
SCHEMBL29644634 0.67 ALDH1A1 (0.39) ALDH1A1POLBCA2TYRSMN1; SMN2
SCHEMBL11300513 0.67 ALDH1A1 (0.39) ALDH1A1POLBCA2TYRSMN1; SMN2
SCHEMBL9685233 0.67 ALDH1A1 (0.33) ALDH1A1POLBCA2TYRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5534646-A OXIDATION RESISTANCE FOR POLYMERS CIBA-GEIGY CORPORATION (US) 1996-07-09 US disclosed