Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9176869 | 0.91 | MAPT (0.57) | MAPTRAB9ALMNAL3MBTL1KMT2A | |
| SCHEMBL8777265 | 0.88 | MRGPRX4 (0.50) | MAPTRAB9ALMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL8567607 | 0.84 | MAPT (0.44) | MAPTRAB9ALMNAL3MBTL1KMT2A | |
| SCHEMBL8325686 | 0.84 | LMNA (0.58) | MAPTRAB9ALMNAL3MBTL1KMT2A | |
| SCHEMBL8799232 | 0.82 | CYP4A11 (0.51) | MAPTRAB9ALMNAL3MBTL1KMT2A | |
| SCHEMBL8799422 | 0.82 | MAPT (0.50) | MAPTRAB9ALMNAL3MBTL1KMT2A | |
| SCHEMBL8777258 | 0.78 | MRGPRX4 (0.53) | — | |
| SCHEMBL5756261 | 0.77 | MAPT (0.61) | MAPTRAB9ALMNAL3MBTL1KMT2A | |
| SCHEMBL4017348 | 0.76 | CA12 (0.48) | MAPTLMNAKMT2ACYP1A2CYP2C19 | |
| SCHEMBL8318954 | 0.76 | LMNA (0.63) | MAPTRAB9ALMNAL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559134-A | Leukotriene-B4 antagonists, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-09-24 | — | — | US | disclosed |