Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.54 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.54 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | RXRA | P19793 | 2/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318954 | 0.93 | LMNA (0.63) | LMNARAB9AMAPTL3MBTL1PTGER1 | |
| SCHEMBL8324027 | 0.90 | MAPT (0.59) | LMNARAB9AMAPTL3MBTL1PTGER1 | |
| SCHEMBL9176869 | 0.86 | MAPT (0.57) | LMNARAB9AMAPTL3MBTL1HPGD | |
| SCHEMBL8322752 | 0.86 | CYP4A11 (0.55) | LMNARAB9AMAPTL3MBTL1HPGD | |
| SCHEMBL8977828 | 0.84 | MAPT (0.57) | LMNARAB9AMAPTL3MBTL1HPGD | |
| SCHEMBL8322717 | 0.83 | PTGER1 (0.77) | LMNARAB9AMAPTL3MBTL1PTGER1 | |
| SCHEMBL9064386 | 0.81 | PTGER1 (0.73) | LMNARAB9AMAPTL3MBTL1PTGER1 | |
| SCHEMBL8327569 | 0.81 | PTGER1 (0.73) | LMNARAB9AMAPTL3MBTL1PTGER1 | |
| SCHEMBL9064881 | 0.80 | PTGER1 (0.76) | MAPTPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL8674880 | 0.80 | TDP1 (0.50) | LMNAL3MBTL1PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733033-B1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LTD (GB) | 1999-12-22 | — | — | EP | disclosed |
| EP-0733033-A1 | PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |