Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799232 | 0.92 | CYP4A11 (0.51) | MAPTRAB9ALMNAL3MBTL1PTGER1 | |
| SCHEMBL8798860 | 0.90 | CYP4F2 (0.46) | MAPTRAB9ALMNAKMT2ALTB4R | |
| SCHEMBL8799655 | 0.86 | LTB4R (0.44) | RAB9ALMNAKMT2ALTB4RLTB4R2 | |
| SCHEMBL8799275 | 0.82 | CYP4F2 (0.57) | RAB9ALTB4RLTB4R2SMN1; SMN2CYP4F2 | |
| SCHEMBL8977828 | 0.82 | MAPT (0.57) | MAPTRAB9ALMNAL3MBTL1KMT2A | |
| SCHEMBL8800386 | 0.80 | LTB4R (0.65) | LTB4RLTB4R2 | |
| SCHEMBL8800182 | 0.78 | LTB4R (0.47) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8798506 | 0.78 | LTB4R (0.49) | LTB4RLTB4R2CYP2C9 | |
| SCHEMBL8327569 | 0.77 | PTGER1 (0.73) | MAPTRAB9ALMNAL3MBTL1PTGER1 | |
| SCHEMBL8799308 | 0.76 | LTB4R (0.45) | RAB9ALMNAKMT2ALTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755381-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B 4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028386-A1 | SUBSTITUTED PYRIDINE LEUKOTRIENE B4 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-10-26 | — | — | WO | disclosed |