Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8977820 | 0.76 | MEN1 (0.33) | ALDH1A1 | |
| SCHEMBL8777264 | 0.76 | MAPK1 (0.32) | ALDH1A1 | |
| SCHEMBL2627807 | 0.76 | CYP1A2 (0.53) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6170678 | 0.74 | TSHR (0.41) | MAPTRAB9AGAAALDH1A1KDM4E | |
| SCHEMBL16834606 | 0.74 | MAPT (0.48) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16369847 | 0.73 | MAPT (0.50) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL22836314 | 0.73 | MAPT (0.50) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29502563 | 0.73 | MAPT (0.50) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1315596 | 0.72 | MAPK1 (0.44) | MAPTCYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL1111138 | 0.71 | P2RX7 (0.61) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559134-A | Leukotriene-B4 antagonists, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-09-24 | — | — | US | disclosed |