Sugi Predict

Sugi Predict / Compounds / SCHEMBL1111138

SCHEMBL1111138

SCHEMBL1111138

COC(=O)c1cccc(C(F)(F)F)n1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P2RX7 Q99572 1/20 0.61
▸ MAPT P10636 3/20 0.55
▸ CYP1A2 P05177 3/20 0.48
▸ GAA P10253 1/20 0.48
▸ RECQL P46063 1/20 0.48
▸ NPC1 O15118 1/20 0.48
▸ TP53 P04637 1/20 0.48
▸ CYP3A4 P08684 1/20 0.48
▸ CYP2C9 P11712 1/20 0.48
▸ CYP2C19 P33261 1/20 0.48
▸ RAB9A P51151 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ MRGPRX4 Q96LA9 1/20 0.47
▸ AHR P35869 1/20 0.47
▸ SDHB P21912 1/20 0.44
▸ IRAK4 Q9NWZ3 3/20 0.43
▸ TUBB4A P04350 1/20 0.43
▸ TUBB P07437 1/20 0.43
▸ TUBA3C P0DPH7 1/20 0.43
▸ TUBA1B P68363 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29418940 1.00 P2RX7 (0.61) P2RX7MAPTCYP1A2GAARECQL
Methyl Alcohol SCHEMBL17966403 0.98 P2RX7 (0.59) P2RX7MAPTCYP1A2GAARECQL
SCHEMBL22836314 0.88 MAPT (0.50) P2RX7MAPTCYP1A2GAARECQL
SCHEMBL29502563 0.88 MAPT (0.50) P2RX7MAPTCYP1A2GAARECQL
SCHEMBL16369847 0.88 MAPT (0.50) P2RX7MAPTCYP1A2GAARECQL
SCHEMBL17138441 0.87 MAPT (0.49) P2RX7MAPTCYP1A2GAARECQL
SCHEMBL7446862 0.87 P2RX7 (0.54) P2RX7MAPTCYP1A2MRGPRX4AHR
SCHEMBL2627807 0.84 CYP1A2 (0.53) P2RX7MAPTCYP1A2GAARECQL
SCHEMBL17138421 0.84 MAPT (0.47) P2RX7MAPTCYP1A2GAARECQL
SCHEMBL17138402 0.83 MAPT (0.46) P2RX7MAPTCYP1A2GAARECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 293 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115536635-A Therapeutically active compounds and methods of use thereof 法国施维雅药厂 2022-12-30 — — CN claimed
CN-115521264-A Therapeutically active compounds and methods of use thereof 法国施维雅药厂 2022-12-27 — — CN claimed
EP-3406608-B1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE LES LABORATOIRES SERVIER SAS (FR) 2021-09-15 — — EP claimed
CN-107417667-B Therapeutically active compounds and methods of use thereof 安吉奥斯医药品有限公司 2020-04-10 — — CN claimed
CN-108912066-A Therapeutical active compound and its application method 安吉奥斯医药品有限公司 2018-11-30 — — CN claimed
EP-3406608-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE Agios Pharmaceuticals, Inc. (US) 2018-11-28 — — EP claimed
US-9656999-B2 Therapeutically active compounds and their methods of use AGIOS PHARMACEUTICALS, INC. (US) 2017-05-23 — — US claimed
US-20170044139-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC 2017-02-16 — — US claimed
US-20260085059-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE SERVIER PHARMACEUTICALS LLC (US) 2026-03-26 — — US disclosed
EP-4647076-A2 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE Les Laboratoires Servier (FR) 2025-11-12 — — EP disclosed
US-12433895-B2 Therapeutically active compounds and their methods of use SERVIER PHARMACEUTICALS LLC (US) 2025-10-07 — — US disclosed
EP-3984997-B1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE SERVIER LAB (FR) 2025-07-30 — — EP disclosed
US-20240391930-A1 SPIROCYCLIC BICYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION GENENTECH, INC. 2024-11-28 — — US disclosed
US-20240335450-A1 TABLET COMPOSITIONS CELGENE CORP (US) 2024-10-10 — — US disclosed
US-20110028520-A1 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS ELI LILLY AND COMPANY (US) 2011-02-03 — — US disclosed
US-20110028520-A1 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS ELI LILLY AND COMPANY (US) 2011-02-03 — — US disclosed
EP-2278968-A2 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS ELI LILLY AND COMPANY (US) 2011-02-02 — — EP disclosed
WO-2009131814-A2 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS ELI LILLY AND COMPANY (US) 2009-10-29 — — WO disclosed
WO-2009131814-A2 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS ELI LILLY AND COMPANY (US) 2009-10-29 — — WO disclosed
CN-1061322-A The safe of benzoic acid derivative class weed killer herbicide MONSANTO CO (US) 1992-05-27 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12433895-B2 Therapeutically active compounds and their methods of use MCL1, TP53, BRDT P2RX7 3486/4885MAPT 3808/4885CYP1A2 4636/4885
US-20240391930-A1 SPIROCYCLIC BICYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION MAG, SGMS1, PMP22 P2RX7 3526/4885MAPT 1241/4885CYP1A2 1440/4885
US-20170044139-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE MCL1, TP53, BRDT P2RX7 3486/4885MAPT 3808/4885CYP1A2 4636/4885
US-20110028520-A1 1,5-DIPHENYL-PYRROLIDIN-2-ONE COMPOUNDS AS CB-1 LIGANDS CNR1, CNR2, GPR119 P2RX7 105/4885MAPT 2623/4885CYP1A2 1036/4885
US-20240335450-A1 TABLET COMPOSITIONS TPP2, HTR3D, SLC5A2 P2RX7 547/4885MAPT 262/4885CYP1A2 499/4885
US-20260085059-A1 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE IDH2, IDH3B, IDH1 P2RX7 2291/4885MAPT 3473/4885CYP1A2 100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.