SCHEMBL8978048

SCHEMBL8978048

O=C(NCC(CNC(=O)c1c(I)c(O)c(I)c(C(=O)NC(CO)CO)c1I)(CNC(=O)c1c(I)c(O)c(I)c(C(=O)NC(CO)CO)c1I)CNC(=O)c1c(I)c(O)c(I)c(C(=O)NC(CO)CO)c1I)c1c(I)c(O)c(I)c(C(=O)NC(CO)CO)c1I

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.48
CYP2C19 P33261 1/20 0.33
HIF1A Q16665 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9269955 0.99 LMNA (0.47) LMNACYP2C19HIF1A
SCHEMBL8978095 0.91 LMNA (0.46) LMNACYP2C19HIF1A
SCHEMBL3430438 0.87 LMNA (0.58) LMNACYP2C19HIF1A
SCHEMBL8423674 0.86 LMNA (0.56) LMNACYP2C19HIF1A
SCHEMBL8635724 0.81 LMNA (0.52) LMNACYP2C19HIF1A
SCHEMBL14777479 0.81 LMNA (0.52) LMNACYP2C19HIF1A
SCHEMBL8635540 0.80 LMNA (0.51) LMNACYP2C19HIF1A
SCHEMBL8413023 0.80 LMNA (0.50) LMNA
SCHEMBL8411034 0.78 LMNA (0.49) LMNA
SCHEMBL8411032 0.78 LMNA (0.49) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0707572-A1 IODINATED OLIGOMERIC COMPOUNDS AND DIAGNOSTIC COMPOSITIONS CONTAINING THE SAME BRACCO S.p.A. (IT) 1996-04-24 EP disclosed
EP-0680652-A1 WAVEFORM BLENDING TECHNIQUE FOR TEXT-TO-SPEECH SYSTEM APPLE COMPUTER, INC. (US) 1995-11-08 EP disclosed
WO-1995001966-A1 IODINATED OLIGOMERIC COMPOUNDS AND DIAGNOSTIC COMPOSITIONS CONTAINING THE SAME BRACCO S.P.A. (IT) 1995-01-19 WO disclosed
WO-1994017517-A1 WAVEFORM BLENDING TECHNIQUE FOR TEXT-TO-SPEECH SYSTEM APPLE COMPUTER, INC. (US) 1994-08-04 WO disclosed