SCHEMBL8978425

SCHEMBL8978425

C=CCc1c(F)cccc1C(=O)c1cccc(F)c1CC=C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.41
CES1 P23141 3/20 0.41
BCHE P06276 1/20 0.41
ALB P02768 1/20 0.39
ALDH1A1 P00352 4/20 0.38
ALOX15 P16050 1/20 0.37
CYP3A4 P08684 1/20 0.37
HPGD P15428 3/20 0.36
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
RAB9A P51151 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
MAPK14 Q16539 1/20 0.35
PTPN1 P18031 1/20 0.35
ERCC5 P28715 1/20 0.35
FEN1 P39748 1/20 0.35
MAPT P10636 1/20 0.35
GABRA1 P14867 1/20 0.34
GABRB2 P47870 1/20 0.34
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27500 0.88 ALB (0.50) CES2CES1BCHEALBALDH1A1
SCHEMBL9221316 0.80 TAAR1 (0.39) CES2CES1ALDH1A1ALOX15CYP3A4
SCHEMBL1325377 0.80 SRD5A1 (0.41) ALDH1A1CYP3A4HPGDKMT2AMEN1
SCHEMBL10930849 0.79 HPGD (0.46) CES2CES1ALDH1A1CYP3A4HPGD
SCHEMBL4926856 0.76 GABRA1 (0.41) ALDH1A1HPGDKMT2AMEN1L3MBTL1
SCHEMBL8978449 0.73 TSHR (0.44) ALDH1A1CYP3A4KMT2AMEN1RAB9A
SCHEMBL1758773 0.73 ALDH1A1 (0.46) ALBALDH1A1ALOX15CYP3A4HPGD
SCHEMBL3181737 0.72 KAT6A (0.35) ALDH1A1HPGDKMT2AMEN1RAB9A
SCHEMBL9074583 0.72 KMT2A (0.46) ALDH1A1ALOX15CYP3A4HPGDKMT2A
SCHEMBL8754981 0.72 KDM4E (0.47) ALDH1A1CYP3A4HPGDMAPTGABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8071413-A None JP disclosed
JP-H0871413-A SEPARATION OF AROMATIC FLUORO-COMPOUND AND AROMATIC NITRO-COMPOUND SEITAI KINOU KENKYUSHO:KK 1996-03-19 JP disclosed