Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995620 | 0.87 | GPR84 (0.38) | NPC1MAPTRAB9ACYP1A2CYP2A6 | |
| SCHEMBL5545747 | 0.83 | MEN1 (0.32) | MEN1RECQLKMT2AHSD17B10 | |
| SCHEMBL5543986 | 0.83 | GPR84 (0.33) | MEN1RECQLKMT2AHSD17B10GPR84 | |
| SCHEMBL7522579 | 0.82 | MEN1 (0.47) | MAPTMEN1RECQLKMT2AGPR84 | |
| SCHEMBL10102260 | 0.81 | GPR84 (0.34) | GPR84 | |
| SCHEMBL14437373 | 0.80 | MEN1 (0.32) | MEN1RECQLKMT2AGPR84 | |
| SCHEMBL13104722 | 0.78 | MAPT (0.39) | NPC1POLBMAPTXBP1RAB9A | |
| SCHEMBL7128153 | 0.77 | PDE4D (0.40) | MAPTCYP1A2GPR84ALDH1A1HPGD | |
| SCHEMBL15277651 | 0.77 | KDM4E (0.32) | NPC1MAPTRAB9AKMT2AHSD17B10 | |
| SCHEMBL9185542 | 0.76 | HSD17B10 (0.33) | NPC1POLBMAPTXBP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740629-B1 | PHOTOCHROMIC COMPOSITIONS AND ARTICLES COMPRISING SILOXANE, ALKYLENE OR SUBSTITUTED ALKYLENE OLIGOMERS | ADVANCED POLYMERIK PTY LTD (AU) | 2011-03-30 | — | — | EP | disclosed |
| US-20070187656-A1 | Photochromic compositions and articles comprising siloxane, alkylene or substituted alkylene oligomers | POLYMERS AUSTRALIA PTY LIMITED (AU) | 2007-08-16 | — | — | US | disclosed |
| US-5573712-A | PHOTOCHROMIC ARTICLE COMPRISING ORGANIC HOST AND THE PHOTOCHROMIC NAPHTHOPYRAN | TRANSITIONS OPTICAL, INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5458814-A | Ophthalmic lenses | TRANSITIONS OPTICAL, INC. (US) | 1995-10-17 | — | — | US | disclosed |
| WO-1995016215-A1 | NOVEL SUBSTITUTED NAPHTHOPYRANS | PPG INDUSTRIES, INC. (US) | 1995-06-15 | — | — | WO | disclosed |