Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962032 | 0.84 | PTGS2 (0.59) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8978826 | 0.79 | PTGS1 (0.43) | PTGS1PTGS2ALOX5KDM4EMEN1 | |
| SCHEMBL9346192 | 0.79 | PTGS1 (0.43) | PTGS1PTGS2ALOX5KDM4EMEN1 | |
| SCHEMBL8978838 | 0.79 | PTGS1 (0.43) | PTGS1PTGS2ALOX5KDM4EMEN1 | |
| SCHEMBL9346182 | 0.76 | PTGS1 (0.53) | PTGS1PTGS2ALOX5MEN1ALDH1A1 | |
| SCHEMBL8961980 | 0.65 | PTGS2 (0.68) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8961971 | 0.65 | PTGS2 (0.68) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8962011 | 0.64 | PTGS2 (0.59) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8962006 | 0.64 | PTGS2 (0.59) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8962056 | 0.64 | PTGS2 (0.58) | PTGS1PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494927-A | INHIBITS ACTIVITY OF 5-LIPOXYGENASE AND-OR CYCLOOXYGENASE | WARNER-LAMBERT COMPANY (US) | 1996-02-27 | — | — | US | disclosed |
| US-5290800-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1994-03-01 | — | — | US | disclosed |
| EP-0449216-A1 | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1991-10-02 | — | — | EP | disclosed |