Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 7/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8978826 | 1.00 | PTGS1 (0.43) | PTGS1PTGS2ALOX5KDM4EMEN1 | |
| SCHEMBL8978838 | 1.00 | PTGS1 (0.43) | PTGS1PTGS2ALOX5KDM4EMEN1 | |
| SCHEMBL8961976 | 0.83 | PTGS2 (0.64) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8961965 | 0.83 | PTGS2 (0.64) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8961997 | 0.83 | PTGS2 (0.64) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8978636 | 0.79 | PTGS1 (0.40) | PTGS1PTGS2ALOX5KDM4EMEN1 | |
| SCHEMBL9346182 | 0.75 | PTGS1 (0.53) | PTGS1PTGS2ALOX5MEN1ALDH1A1 | |
| SCHEMBL8962142 | 0.71 | PTGS2 (0.60) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8962140 | 0.71 | PTGS2 (0.60) | PTGS1PTGS2ALOX5 | |
| SCHEMBL8961993 | 0.71 | PTGS2 (0.60) | PTGS1PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5290800-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1994-03-01 | — | — | US | disclosed |
| US-5143928-A | Inhibitors of cyclooxygenase and lipoxygenase | WARNER-LAMBERT COMPANY (US) | 1992-09-01 | — | — | US | disclosed |