Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084465 | 0.84 | SIRT2 (0.44) | SIRT2HTR1A | |
| SCHEMBL9069663 | 0.81 | SIRT2 (0.44) | SIRT2 | |
| SCHEMBL9258121 | 0.80 | SIRT2 (0.42) | SIRT2 | |
| SCHEMBL1040467 | 0.78 | SIRT2 (0.42) | SIRT2 | |
| SCHEMBL5689049 | 0.76 | SIRT2 (0.42) | SIRT2 | |
| SCHEMBL21096113 | 0.76 | KIF11 (0.52) | SIRT2 | |
| SCHEMBL18937780 | 0.74 | SIRT2 (0.54) | SIRT2 | |
| SCHEMBL4382643 | 0.73 | SIRT2 (0.54) | SIRT2 | |
| SCHEMBL1041048 | 0.73 | SIRT2 (0.49) | SIRT2 | |
| SCHEMBL7818117 | 0.73 | SIRT2 (0.44) | SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491161-A | TREATMENT OF SEX HORMONE DEPENDANT DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-02-13 | — | — | US | disclosed |
| US-5457102-A | Sex hormone inhibitor, antiestrogens, aromatase inhibitor | JANSSEN PHARMACEUTICA, N.V. (BE) | 1995-10-10 | — | — | US | disclosed |
| EP-0625155-A1 | PYRROLOIMIDAZOLYL AND IMIDAZOPYRIDINYL SUBSTITUTED 1H-BENZIMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015079-A1 | PYRROLOIMIDAZOLYL AND IMIDAZOPYRIDINYL SUBSTITUTED 1H-BENZIMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-08-05 | — | — | WO | disclosed |