Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.42 |
| ▸ | NMBR | P28336 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9263573 | 0.89 | SIRT2 (0.41) | SIRT2NMBROPRM1OPRD1MAPT | |
| SCHEMBL9261939 | 0.82 | CYP1A2 (0.41) | SIRT2OPRM1OPRD1MAPT | |
| SCHEMBL8979144 | 0.80 | SIRT2 (0.42) | SIRT2 | |
| SCHEMBL11056190 | 0.80 | CYP11B1 (0.44) | OPRM1OPRD1MAPT | |
| SCHEMBL5689049 | 0.80 | SIRT2 (0.42) | SIRT2 | |
| SCHEMBL4033379 | 0.77 | HDAC1 (0.43) | SIRT2 | |
| SCHEMBL7084465 | 0.76 | SIRT2 (0.44) | SIRT2 | |
| SCHEMBL9263704 | 0.76 | LMNA (0.36) | SIRT2OPRM1OPRD1MAPT | |
| SCHEMBL18937780 | 0.73 | SIRT2 (0.54) | SIRT2NMBR | |
| SCHEMBL1037593 | 0.72 | SIRT2 (0.50) | SIRT2NMBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428160-A | Condensation of imidazole derivative with cyano- or halo-substituted benzene derivative containing leaving group esterified with carboxylic or sulfonic acid | CIBA-GEIGY CORPORATION (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0165904-B1 | SUBSTITUTED BICYCLE COMPOUNDS | CIBA-GEIGY AG (CH) | 1991-04-10 | — | — | EP | disclosed |
| US-4889861-A | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors | CIBA-GEIGY CORP. (US) | 1989-12-26 | — | — | US | disclosed |
| US-4728645-A | THROMBOXANE SYNTHETASE INHIBITORS | CIBA-GEIGY CORPORATION (US) | 1988-03-01 | — | — | US | disclosed |
| EP-0165904-A2 | Substituted bicycle compounds | CIBA-GEIGY AG (CH) | 1985-12-27 | — | — | EP | disclosed |