Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219158 | 0.90 | TDP1 (0.46) | TDP1ALOX15ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL499437 | 0.87 | TDP1 (0.70) | TDP1TSHRSMN1; SMN2LMNASLC22A6 | |
| SCHEMBL5495547 | 0.78 | TDP1 (0.64) | TDP1ALOX15TSHRSMN1; SMN2SLC22A6 | |
| SCHEMBL386700 | 0.78 | ALOX15 (0.39) | TDP1ALOX15ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL16925719 | 0.76 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2LMNASLC22A6 | |
| SCHEMBL22151 | 0.76 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2LMNASLC22A6 | |
| SCHEMBL17517216 | 0.76 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2LMNASLC22A6 | |
| SCHEMBL165643 | 0.76 | TDP1 (1.00) | TDP1TSHRSMN1; SMN2LMNASLC22A6 | |
| SCHEMBL27467413 | 0.76 | TSHR (0.41) | TDP1ALOX15ALDH1A1TSHRHSD17B10 | |
| SCHEMBL15249460 | 0.75 | TDP1 (0.74) | TDP1ALOX15ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0499180-B1 | Dental/medical composition for restorative/prosthetic purposes and its use | DENTSPLY GMBH (DE) | 1996-05-15 | — | — | EP | disclosed |