Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8027585 | 0.87 | MPO (0.50) | MPOPOLBRAB9AMTNR1ARIPK1 | |
| SCHEMBL13329783 | 0.83 | MAPK8 (0.52) | MPOMAOBRIPK1P2RX7MAPK8 | |
| SCHEMBL3316261 | 0.83 | MTNR1A (0.61) | POLBMTNR1ACHRNA7FFAR1 | |
| SCHEMBL30488619 | 0.81 | MAOB (0.53) | MAOBGSK3BBACE1RIPK1DAO | |
| SCHEMBL21222818 | 0.81 | MAOB (0.53) | MAOBGSK3BBACE1RIPK1DAO | |
| SCHEMBL3576683 | 0.80 | MAOB (0.47) | MPOMAOBGSK3BBACE1RIPK1 | |
| SCHEMBL20609634 | 0.80 | MAOB (0.49) | MAOBPOLBRAB9AGSK3BBACE1 | |
| SCHEMBL12851277 | 0.79 | TAAR1 (0.55) | MAOBRAB9AMTNR1ARIPK1 | |
| SCHEMBL30637597 | 0.79 | FFAR1 (0.59) | MAOBPOLBFFAR1FFAR4 | |
| SCHEMBL2397247 | 0.79 | FFAR1 (0.59) | MAOBPOLBFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512594-A | ADMINISTERING TO TREAT A MEDICAL CONDITION MEDIATED BY ONE OR MORE LEUKOTRIENES | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |