Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 6/20 | 0.55 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9153918 | 0.90 | LTB4R2 (0.45) | LTB4R2BDKRB1AGTR1AGTR2ACHE | |
| SCHEMBL8671881 | 0.89 | LTB4R2 (0.57) | LTB4R2BDKRB1SLC6A3SLC6A4AGTR1 | |
| SCHEMBL8979799 | 0.89 | LTB4R2 (0.53) | LTB4R2BDKRB1SLC6A3SLC6A4AGTR1 | |
| SCHEMBL9280307 | 0.88 | LTB4R2 (0.46) | LTB4R2BDKRB1AGTR1AGTR2 | |
| SCHEMBL8979895 | 0.87 | LTB4R2 (0.49) | LTB4R2BDKRB1SLC6A3SLC6A4AGTR1 | |
| SCHEMBL8979749 | 0.82 | LTB4R2 (0.48) | LTB4R2BDKRB1SLC6A3SLC6A4AGTR1 | |
| SCHEMBL8670621 | 0.82 | LTB4R2 (0.51) | LTB4R2BDKRB1SLC6A3SLC6A4AGTR1 | |
| SCHEMBL9024939 | 0.81 | LTB4R2 (0.58) | LTB4R2AGTR1BRS3 | |
| SCHEMBL8673632 | 0.81 | LTB4R2 (0.48) | LTB4R2BDKRB1SLC6A3SLC6A4AGTR1 | |
| SCHEMBL9154927 | 0.79 | ACHE (0.43) | LTB4R2BDKRB1AGTR1ACHEBRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565464-A | Compounds having angiotensine II antagonistic activity | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1996-10-15 | — | — | US | disclosed |
| WO-1993003018-A1 | COMPOUNDS HAVING ANGIOTENSINE II ANTAGONISTIC ACTIVITY | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1993-02-18 | — | — | WO | disclosed |