SCHEMBL8980214

SCHEMBL8980214

O=C(O)c1c(-c2ccccc2)ccc2ocnc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.40
ALDH1A1 P00352 5/20 0.38
HSD17B10 Q99714 3/20 0.38
TSHR P16473 2/20 0.38
LMNA P02545 1/20 0.38
FOLH1 Q04609 1/20 0.38
SMN1; SMN2 Q16637 4/20 0.38
NPC1 O15118 4/20 0.38
RAB9A P51151 3/20 0.38
CTNNB1 P35222 1/20 0.38
WNT3A P56704 1/20 0.38
DHODH Q02127 2/20 0.37
NR4A2 P43354 1/20 0.37
PIN1 Q13526 1/20 0.36
XDH P47989 1/20 0.36
SLC22A12 Q96S37 1/20 0.36
KMO O15229 1/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8980290 0.76 PIN1 (0.39) ALDH1A1HSD17B10LMNASMN1; SMN2NPC1
SCHEMBL23521242 0.73 FOLH1 (0.53) ALDH1A1HSD17B10TSHRFOLH1MEN1
SCHEMBL1884974 0.73 NR4A2 (0.43) ADORA2AALDH1A1HSD17B10TSHRLMNA
SCHEMBL27776114 0.73 NPC1 (0.38) ALDH1A1HSD17B10TSHRFOLH1SMN1; SMN2
SCHEMBL9336421 0.72 ALOX5AP (0.42) ALDH1A1HSD17B10TSHRSMN1; SMN2NPC1
SCHEMBL12637425 0.70 NR4A2 (0.42) ADORA2AALDH1A1HSD17B10TSHRLMNA
SCHEMBL21879681 0.69 CDC25B (0.50) ALDH1A1TSHRLMNAFOLH1SMN1; SMN2
SCHEMBL8980352 0.69 KDM4E (0.45) ALDH1A1HSD17B10TSHRLMNAFOLH1
SCHEMBL9197102 0.68 ACVR1 (0.42) ADORA2AALDH1A1HSD17B10SMN1; SMN2NPC1
SCHEMBL984268 0.68 PIN1 (0.52) ALDH1A1TSHRLMNASMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0591786-B1 Photosensitive composition FUJI PHOTO FILM CO LTD (JP) 1996-05-15 EP disclosed
EP-0591786-A2 Photosensitive composition FUJI PHOTO FILM CO., LTD. (JP) 1994-04-13 EP disclosed