Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 15/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980376 | 0.88 | CYP19A1 (0.65) | GUSBCYP19A1KDM4EALDH1A1ABCB11 | |
| SCHEMBL8980363 | 0.79 | CYP19A1 (0.72) | CYP19A1LMNAMAPTCYP3A4 | |
| SCHEMBL8980211 | 0.77 | CYP19A1 (0.67) | CYP19A1ALDH1A1NR3C1PGRLMNA | |
| SCHEMBL8980219 | 0.77 | CYP19A1 (0.67) | CYP19A1ALDH1A1NR3C1PGRLMNA | |
| SCHEMBL13518386 | 0.75 | GUSB (0.75) | GUSBCYP19A1KDM4EALDH1A1ABCB11 | |
| SCHEMBL11112810 | 0.75 | GUSB (0.61) | GUSBCYP19A1KDM4EALDH1A1ABCB11 | |
| SCHEMBL11425309 | 0.74 | GUSB (0.60) | GUSBCYP19A1KDM4EALDH1A1ABCB11 | |
| SCHEMBL6524579 | 0.74 | GUSB (0.60) | GUSBCYP19A1KDM4EALDH1A1ABCB11 | |
| SCHEMBL11137065 | 0.74 | GUSB (0.60) | GUSBCYP19A1KDM4EALDH1A1ABCB11 | |
| SCHEMBL9240286 | 0.74 | GUSB (0.60) | GUSBCYP19A1KDM4EALDH1A1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519051-A | AROMATASE INHIBITORS USEFUL FOR TREATMENT OF DISEASES CAUSED BY EXCESS OF ESTROGEN, FOR EXAMPLE, BREAST CANCER, UTERINE CANCER | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1996-05-21 | — | — | US | disclosed |
| EP-0582713-A1 | NOVEL OXA- OR AZASTEROID DERIVATIVE | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1994-02-16 | — | — | EP | disclosed |