Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.57 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10346126 | 0.89 | KMT2A (0.65) | KMT2APOLBHDAC2HDAC3BRAF | |
| SCHEMBL11574206 | 0.87 | HDAC2 (0.53) | KMT2APOLBHDAC2HDAC3BRAF | |
| SCHEMBL4409156 | 0.83 | KCNK3 (0.65) | KMT2APOLBHDAC2HDAC3HDAC1 | |
| SCHEMBL6346820 | 0.83 | KMT2A (0.65) | KMT2APOLBKCNK3KCNK9CACNA1B | |
| SCHEMBL3530325 | 0.83 | KMT2A (0.69) | KMT2APOLBKCNK3KCNK9CACNA1B | |
| SCHEMBL8980390 | 0.82 | ALDH1A1 (0.53) | KMT2APOLBHDAC1NPC1RAB9A | |
| SCHEMBL8278418 | 0.81 | NPC1 (0.71) | KMT2APOLBKCNK3KCNK9CACNA1B | |
| SCHEMBL11322912 | 0.79 | RAB9A (0.73) | KMT2APOLBKCNK3KCNK9NPC1 | |
| SCHEMBL30017323 | 0.79 | NPC1 (0.73) | KMT2APOLBHDAC2HDAC3HDAC1 | |
| SCHEMBL21473657 | 0.79 | NPC1 (0.73) | KMT2APOLBHDAC2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |