Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531639 | 0.91 | KMT2A (0.42) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL8980246 | 0.86 | MEN1 (0.44) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL8177483 | 0.85 | KMT2A (0.39) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL9632315 | 0.84 | KMT2A (0.42) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL7127125 | 0.83 | KMT2A (0.44) | KMT2AMEN1NPC1MAPTALDH1A1 | |
| SCHEMBL9534457 | 0.81 | MAPT (0.45) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL9630982 | 0.81 | KMT2A (0.36) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL9632107 | 0.80 | MAPT (0.60) | KMT2AMEN1MAPTTDP1PPARG | |
| SCHEMBL9630952 | 0.79 | TTPA (0.41) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL10640704 | 0.79 | PPARG (0.46) | KMT2AMEN1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556830-B1 | Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl)chromans | LONZA AG (CH) | 1996-04-24 | — | — | EP | disclosed |
| EP-0556831-B1 | Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl)chromans | LONZA AG (CH) | 1995-11-02 | — | — | EP | disclosed |
| US-5310952-A | Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl) chromans | LONZA LTD. (CH) | 1994-05-10 | — | — | US | disclosed |
| US-5284961-A | Process for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl) chromans | LONZA LTD. (CH) | 1994-02-08 | — | — | US | disclosed |
| EP-0556830-A1 | Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl)chromans | LONZA AG (CH) | 1993-08-25 | — | — | EP | disclosed |
| EP-0556831-A1 | Method for the preparation of 6-hydroxy-2,5,7,8-tetraalkyl-2-(4-aminophenoxymethyl)chromans | LONZA AG (CH) | 1993-08-25 | — | — | EP | disclosed |
| US-5104888-A | Anticholesterol or antidiabetic agents | SANKYO COMPANY, LIMITED (JP) | 1992-04-14 | — | — | US | disclosed |
| EP-0207581-B1 | THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND USE | SANKYO COMPANY LIMITED (JP) | 1990-09-12 | — | — | EP | disclosed |
| EP-0139421-B1 | THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1988-04-27 | — | — | EP | disclosed |
| EP-0207581-A2 | Thiazolidine derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | disclosed |
| US-4572912-A | Thiazolidine derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1986-02-25 | — | — | US | disclosed |
| EP-0139421-A1 | Thiazolidine derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1985-05-02 | — | — | EP | disclosed |