Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | LDHA | P00338 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3628705 | 0.83 | HTT (0.68) | HTTSMN1; SMN2CTBP2TDP1LDHA | |
| SCHEMBL240822 | 0.81 | KDM4E (0.74) | HTTSMN1; SMN2CTBP2TDP1LDHA | |
| SCHEMBL1525068 | 0.81 | HTT (0.66) | HTTSMN1; SMN2CTBP2TDP1LDHA | |
| SCHEMBL48525 | 0.81 | HTT (0.66) | HTTSMN1; SMN2CTBP2LDHAKDM4E | |
| SCHEMBL28709451 | 0.81 | HTT (0.66) | HTTSMN1; SMN2CTBP2LDHAKDM4E | |
| SCHEMBL5257976 | 0.79 | HTT (0.63) | HTTSMN1; SMN2CTBP2TDP1LDHA | |
| SCHEMBL3231393 | 0.79 | HTT (0.63) | HTTSMN1; SMN2CTBP2TDP1LDHA | |
| SCHEMBL3649876 | 0.79 | HTT (0.63) | HTTSMN1; SMN2CTBP2TDP1LDHA | |
| SCHEMBL226124 | 0.79 | HTT (0.63) | HTTSMN1; SMN2CTBP2TDP1LDHA | |
| SCHEMBL1067193 | 0.79 | HTT (0.63) | HTTSMN1; SMN2CTBP2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5519051-A | AROMATASE INHIBITORS USEFUL FOR TREATMENT OF DISEASES CAUSED BY EXCESS OF ESTROGEN, FOR EXAMPLE, BREAST CANCER, UTERINE CANCER | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1996-05-21 | — | — | US | disclosed |
| EP-0582713-A1 | NOVEL OXA- OR AZASTEROID DERIVATIVE | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1994-02-16 | — | — | EP | disclosed |