SCHEMBL226124

SCHEMBL226124

COc1ccc(CC(=O)Cl)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.63
SMN1; SMN2 Q16637 2/20 0.58
CTBP2 P56545 1/20 0.56
LDHA P00338 1/20 0.53
ALDH1A1 P00352 2/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C19 P33261 1/20 0.53
USP2 O75604 1/20 0.53
TP53 P04637 1/20 0.53
KDM4E B2RXH2 1/20 0.53
POLB P06746 1/20 0.53
HPGD P15428 1/20 0.53
F2RL1 P55085 1/20 0.52
MAPT P10636 1/20 0.51
NPC1 O15118 1/20 0.51
PKM P14618 1/20 0.51
LMNA P02545 1/20 0.51
CNR2 P34972 1/20 0.51
TDP1 Q9NUW8 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3299784 0.93 NPC1 (0.62) HTTSMN1; SMN2CTBP2ALDH1A1USP2
SCHEMBL9580307 0.83 PTGS1 (0.73) HTTSMN1; SMN2ALDH1A1CYP3A4CYP2C19
SCHEMBL27383168 0.83 HTT (0.63) HTTSMN1; SMN2CTBP2LDHAALDH1A1
SCHEMBL3628705 0.83 HTT (0.68) HTTSMN1; SMN2CTBP2LDHAALDH1A1
Methane SCHEMBL7682688 0.82 AKR1C3 (0.71) HTTSMN1; SMN2ALDH1A1CYP3A4CYP2C19
SCHEMBL4194796 0.82 CA2 (0.46) HTTCTBP2ALDH1A1HPGDNPC1
SCHEMBL28709451 0.81 HTT (0.66) HTTSMN1; SMN2CTBP2LDHAALDH1A1
SCHEMBL240822 0.81 KDM4E (0.74) HTTSMN1; SMN2CTBP2LDHAALDH1A1
SCHEMBL48525 0.81 HTT (0.66) HTTSMN1; SMN2CTBP2LDHAALDH1A1
SCHEMBL1525068 0.81 HTT (0.66) HTTSMN1; SMN2CTBP2LDHAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118496175-A TRADD inhibitor derivative and preparation method and application thereof 安徽医科大学 2024-08-16 CN claimed
CN-118374192-A Anti-sticking polytetrafluoroethylene coating and preparation method thereof 北京耐默科技有限公司 2024-07-23 CN claimed
CN-117510429-A Compound containing methyl isoxazole structure, and preparation method and application thereof 中国农业大学 2024-02-06 CN claimed
CN-117209448-A Process for the preparation of (benzo) thiazole-containing thio/selenoacetamides and derivatives thereof 济宁医学院 2023-12-12 CN claimed
CN-117126119-A Preparation method of (benzo) thiazole amide-containing compound 济宁医学院 2023-11-28 CN claimed
CN-111635435-B Bivalent copper complex containing biphosphine ortho-carborane ligand, and preparation method and application thereof 上海应用技术大学 2023-04-28 CN claimed
EP-2114847-B1 METHOD FOR THE PRODUCTION OF 2,4-DIHYDROXYPHENYL-BENZYL KETONES PLANT HEALTH CARE INC (US) 2017-03-22 EP claimed
CN-103626703-B The preparation method of chirality demethyl coclaurine and derivative thereof ZHUHAI RUNDU PHARMACEUTICAL CO., LTD. (CN) 2015-11-11 CN claimed
CN-103626703-A Preparation method of chiral higenamine and derivatives of chiral higenamine ZHUHAI RUNDU PHARMACEUTICAL CO LTD 2014-03-12 CN claimed
CN-101610989-B Method for the production of 2,4-dihydroxyphenyl-4-methoxybenzyl ketones PLANT HEALTH CARE INC 2013-05-15 CN claimed
EP-1506176-B1 AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PFIZER ITALIA SRL (IT) 2013-04-24 EP claimed
US-8324431-B2 Process for preparing 2,4-dihydroxyphenyl 4-methoxybenzyl ketones PLANT HEALTH CARE, INC. (US) 2012-12-04 US claimed
US-20100121082-A1 PROCESS FOR PREPARING 2,4-DIHYDROXYPHENYL 4-METHOXYBENZYL KETONES PLANT HEALTH CARE, INC. 2010-05-13 US claimed
CN-101610989-A Preparation 2, the method for 4-dihydroxy phenyl-4-methoxy-benzyl ketone BAYER CROPSCIENCE AG (DE) 2009-12-23 CN claimed
EP-1461335-B1 2-HETEROARYLCARBOXYLIC ACID AMIDES BAYER HEALTHCARE AG (DE) 2007-02-28 EP claimed
US-5021197-A Reacting a p-dialkylsulfoniophenol with a carbonyl halogenide in the presence of a secondary amine MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 1991-06-04 US claimed
CN-116836153-B CDK9-Cyclin T1 protein interaction inhibitor and application thereof 厦门大学 2026-05-19 CN disclosed
EP-4676923-A1 BIARYLAMIDE DERIVATIVES AND THEIR USE AS PKMYT1 INHIBITORS Cancer Research Technology Limited (GB) 2026-01-14 EP disclosed
US-4000154-A 3-Substituted-6β-(amino- and acylamino)-7-oxo-1,3-diazabicyclo[3.2.0]-h SMITHKLINE CORPORATION (US) 1976-12-28 US disclosed
US-3976653-A ANALGESIC ANTAGONIST STERLING DRUG INC. (US) 1976-08-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100121082-A1 PROCESS FOR PREPARING 2,4-DIHYDROXYPHENYL 4-METHOXYBENZYL KETONES PHF2, CYP2F1, CYP4F3 HTT 1249/4885SMN1; SMN2 4007/4885CTBP2 3004/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.