Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10102343 | 0.83 | PLAU (0.51) | ALDH1A1PLAUMAPTRAB9AL3MBTL1 | |
| SCHEMBL8980494 | 0.79 | MAPK1 (0.48) | ALDH1A1PLAUMAPTPOLBCYP3A4 | |
| SCHEMBL28305506 | 0.78 | IKBKB (0.41) | IKBKBALDH1A1RCE1PLAUMAPT | |
| SCHEMBL3138019 | 0.78 | IKBKB (0.49) | IKBKBALDH1A1CDC25BCASP6RCE1 | |
| SCHEMBL11458731 | 0.78 | MAPT (0.58) | ALDH1A1CDC25BCASP6RCE1MAPT | |
| SCHEMBL6424653 | 0.77 | MAPT (0.52) | PLAUMAPTPOLBL3MBTL1SRD5A2 | |
| SCHEMBL2978267 | 0.76 | PLA2G10 (0.63) | PLAUMAPTPOLBRAB9AL3MBTL1 | |
| SCHEMBL24574268 | 0.76 | ALDH1A1 (0.71) | IKBKBALDH1A1CDC25BCASP6RCE1 | |
| SCHEMBL29700063 | 0.76 | ALDH1A1 (0.71) | IKBKBALDH1A1CDC25BCASP6RCE1 | |
| SCHEMBL7199268 | 0.75 | MAPT (0.67) | ALDH1A1PLAUMAPTRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | disclosed |